医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是武汉大学六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759376
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵郭德银章晓联万芪李红良
千人计划入选: 霍文哲张发明、于学杰
青年千人计划入选: 陈实蒋卫钟波张好建、陈强、罗孟成、邓迎峰
百千万人才工程选者: 舒红兵、黄从新章晓联 
长江学者: 董晨舒红兵李红良
万人计划: 领军人才:舒红兵唐其柱李红良   青年拔尖人才: 刘天罡 、王连荣王培刚                
教育部新世纪优秀人才: 何小华 于红刚 李雁郑芳、胡锦跃、黄鹤
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姓名:孙晓平

单位:武汉大学医学部基础医学院病原生物学系

职称:微生物室副主任、教授、博导

邮箱:xsun6@whu.edu.cn

联系电话:027-68759361

研究方向:

1.主要研究小分子化合物对肿瘤病毒编码的蛋白以及对肿瘤细胞生长的抑制的分子机制。

2.研究Hsp90和疱疹病毒蛋白激酶相互作用的分子机制。


 











代表性论著:

1.Chao Wang, Huan Wang, Yaqian Zhang, Wei Guo, Cong Long, Limei Liu, Xiaoping Sun. Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism. Oncology Reports 2017, 37(2017)2109-2120.

2.Chao Wang, Jingchao Wang, Wei Guo, Cong Long, Huan Wang, Xiaoping Sun. Amino acids essential for the interaction between cellular heat shock protein 90 and a Kaposi’s sarcoma-associated herpesvirus-encoded protein kinase ORF36. VIROLOGICA SINICA 2016, 31(2016)509.

3.J. Wang, W. Guo, C. Long, H. Zhou, H. Wang, X. Sun. The split Renilla luciferase complementation assay is useful for identifying the interaction of Epstein-Barr virusprotein kinase BGLF4 and a heat shock protein Hsp90. Acta virol 2016, 60(1):62-70. 

4.C. Long, W. Guo, H. Zhou, J. Wang, H. Wang, X. Sun. Triptolide decreases expression of latency-associated nuclear antigen 1 and reduces viral titers in Kaposi’s sarcoma-associated herpesvirus-associated primary effusion lymphoma cells. International Jounral of Oncology 2016, 48(4):1519-30. 

5.C Long, J Wang, W Guo, H Wang, C Wang, Y Liu, X Sun. Triptolide inhibits transcription of hTERT through down-regulation of transcription factor specificity protein 1 in primary effusion lymphoma cells. Biochem Biophys Res Commun 2016, 469(2016):87-93. 

6.H. Zhou, W. Guo, C. Long, H. Wang, J. Wang, X. Sun. Triptolide inhibits proliferation of Epstein-Barr virus-positive B lymphocytes by down-regulating expression of a viral protein LMP1. Biochem Biophys Res Commun 2015, 456 (2015) 815-820.

7.Xiaoping Sun, Jillian A. Bristol, Satoko Iwahoria, Stacy R. Hagemeier, Qiao Meng, Elizabeth A. Barlow, Joyce D. Fingeroth, Vera L. Tarakanova, Robert F. Kalejta and Shannon C. Kenney. Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells. J Virol. 2013, 87:10126-10138. 

8.Shidong Ma, Subramanya Hegde, Ken Young, Ruth Sullivan, Deepika Rajesh , Ying Zhou, Ewa Jankowska-Gan, William Burlingham, Xiaoping Sun, Margaret Gulley, Weihua Tang, Jenney E. Gumperz, and Shannon C. Kenney. A new model of EBV infection reveals an important role for early lytic viral protein expression in the development of lymphomas. J Virol 2011, 85:165-177. 

9.Xiaoping Sun, Shannon C. Kenney. Hsp90 inhibitors: a potential treatment for latent EBV infection? Cell Cycle 2010, 9(9):1665-66. 

10.Xiaoping Sun, Elizabeth A. Barlow, Shidong Ma, Stacy R. Hagemeier, Sarah J. Duellman, Richard R. Burgess, Judy Tellam, Rajiv Khanna, and Shannon C. Kenney. Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism. Proc Natl Acad Sci USA 2010, 107(7):3146-51.

11.Prasanna M. Bhende, Sarah J. Dickerson, Xiaoping Sun, Wenhai Feng, Shannon C. Kenney.  X-box-binding protein 1 activates lytic Epstein-Barr virus gene expression in combination with Protein Kinase D. J Virol 2007, 81:7363-7370. 

12.Xiaoping Sun and Anne E. Simon. A cis-replication element functions in both orientations to enhance replication of Turnip crinkle virus. Virology 2006, 352:39-51. 

13.Xiaoping Sun, Guohua Zhang, and Anne E. Simon. Short internal sequences involved in replication and virion accumulation in a subviral RNA of Turnip crinkle virus. J Virol 2005, 79:512-524.

14.Xiaoping Sun and Anne E. Simon. Fitness of a Turnip crinkle virus satellite RNA correlates with a sequence-nonspecific hairpin and flanking sequences that enhance replication and repress the accumulation of virions. J Virol 2003, 77:7880-7889.