医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是武汉大学六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759376
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵郭德银章晓联万芪李红良
千人计划入选: 霍文哲张发明、于学杰
青年千人计划入选: 陈实蒋卫钟波张好建、陈强、罗孟成、邓迎峰
百千万人才工程选者: 舒红兵、黄从新章晓联 
长江学者: 董晨舒红兵李红良
万人计划: 领军人才:舒红兵唐其柱李红良   青年拔尖人才: 刘天罡 、王连荣王培刚                
教育部新世纪优秀人才: 何小华 于红刚 李雁郑芳、胡锦跃、黄鹤
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姓名:孙桂鸿

单位:武汉大学医学部基础医学院病原生物学系

职称:教授、博导

邮箱:ghsunlab@whu.edu.cn

联系电话:13307180026

研究方向:

1.病毒感染免疫及其致病机理:主要聚焦HBV感染、免疫逃逸和被免疫清除过程中,HBV与宿主之间的相互作用,以及相互作用后导致的不同疾病的机理。

2.利用小分子调控病毒复制和肿瘤的产生: 主要目标是尝试利用小分子多肽、小分子RNA等干扰病毒感染和复制,抑制肿瘤的产生。


 











代表性论著:

1.Xiong Q, Wu S, Wang J, Zeng X, Chen J, Wei M, Guan H, Fan C, Chen L, Guo D, Sun G. Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression. Cell Biosci. 2017 Apr 12;7:16. 

2.Liu Z, Song F, Ma ZL, Xiong Q, Wang J, Guo D, Sun G. Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce Cytotoxicity. Sci Rep. 2016 Sep 6;6:32658. 

3.Sun G, Roediger J, Shi YB. Thyroid hormone regulation of adult intestinal stem cells: Implications on intestinal development and homeostasis. Rev Endocr Metab Disord. 2016 Dec;17(4):559-569.

4.He M, Lin Y, Tang Y, Liu Y, Zhou W, Li C, Sun G, Guo M. miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells. Aging (Albany NY). 2016 Jul;8(7):1442-56.

5.Sun G, Fu L, Wen L, Shi YB. Activation of Sox3 gene by thyroid hormone in the developing adult intestinal stem cell during Xenopus metamorphosis. Endocrinology. 2014 Dec;155(12):5024-32.

6.Luu N, Wen L, Fu L, Fujimoto K, Shi YB, Sun G. Differential regulation of two histidine ammonia-lyase genes during Xenopus development implicates distinct functions during thyroid hormone-induced formation of adult stem cells. Cell Biosci. 2013 Nov 13;3(1):43.

7.Sun G, Fu L, Shi YB. Epigenetic regulation of thyroid hormone-induced adult intestinal stem cell development during anuran metamorphosis. Cell Biosci. 2014 Nov 28;4:73

8.Liu Z, Xiang Y, Sun G. The KCTD family of proteins: structure, function, disease relevance. Cell Biosci. 2013 Nov 24;3(1):45.

9.Sun G, Heimeier RA, Fu L, Hasebe T, Das B, Ishizuya-Oka A, Shi YB. Expression profiling of intestinal tissues implicates tissue-specific genes and pathways essential for thyroid hormone-induced adult stem cell development. Endocrinology. 2013 Nov;154(11):4396-407.