医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是武汉大学六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759376
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵郭德银章晓联万芪李红良
千人计划入选: 霍文哲张发明、于学杰
青年千人计划入选: 陈实蒋卫钟波张好建、陈强、罗孟成、邓迎峰
百千万人才工程选者: 舒红兵、黄从新章晓联 
长江学者: 董晨舒红兵李红良
万人计划: 领军人才:舒红兵唐其柱李红良   青年拔尖人才: 刘天罡 、王连荣王培刚                
教育部新世纪优秀人才: 何小华 于红刚 李雁郑芳、胡锦跃、黄鹤
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姓名:李晖

单位: 武汉大学医学部基础医学院医学病毒学研究所

职称: 教授、博导

邮箱: somhli@whu.edu.cn

联系电话:027-68758898

研究方向:

1.病毒感染与天然免疫:聚焦病毒感染的原发靶点--人正常上皮细胞,建立体外2D和3D感染模型研究病毒感染宿主早期天然免疫应答。

2.细胞重编程与组织再生:通过细胞重编程建立人源正常细胞,应用于抗病毒药物筛选和组织再生研究。


 











代表性论著:

1.Yaqi Zhu,Yan Yang, Juanjuan Guo, Ying Dai, Lina Ye, Jianbin Qiu, Zhihong Zeng, Xiaoting Wu, Yanmei Xing, Xiang Long, Xufeng Wu , Lin Ye, Shubin Wang, Hui Li*. Ex Vivo 2D and 3D HSV-2 infection model using human normal vaginal epithelial cells. Oncotarget  2017, Feb 28;8(9):15267-15282. doi:10.18632/oncotarget.14840

2.Dan Liu, Lei Cui, Yuan Wang, Guifang Yang,Jing He,Ruidong Hao, Chengpeng Fan, Mengmeng Qu, Zhepeng Liu,Min Wang, Lang Chen, Hui Li,Deyin Guo. Hepatitis B e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 activity.  Hepatology 2016 Aug;64(2):390-404. 

3.Wenqiang Feng, Juanjuan Guo, Haiyan Huang, Bo Xia, Hongya Liu, Jie Li, Shaolin Lin, Tiyuan Li, Jianjun Liu, Hui Li*. Human normal bronchial epithelial cells: a novel in vitro cell model for toxicity evaluation.  PLoS One 2015, 10(4): e0123520 

4.Hongya Liu, Kai Chen, WenqiangFeng, JuanjuanGuo, Hui Li*. HSV-2 increases TLR4-dependent phosphorylated IRFs and IFN-b induction in Cervical Epithelial Cells.  PLoS One 2014, 9(4): e94806 

5.Hongya Liu, Kai Chen, WenqiangFeng, Xinxing Wu, Hui Li*. TLR4-MyD88/Mal-NF-kB axis is involved in infection of HSV-2 in human cervical epithelial cells. PLoS One 2013, 8:( 11): e80327 

6.Hui Li, Xiaoling Li, Yun Wei, Yun Tan, Xuefeng Liu, Xinxing Wu. HSV-2 infection induces TLRs and NF-B-dependent cytokines in human cervical eptithelial cells. Bio Biophy Res Comm 2009;79(3):686-90. 

7.Hui Li, PadmajaGade, ShreeramNallar, AbhijtRaha, Sanjit Roy, SreenivasuKarra, and Dhan V. Kalvakolanu. The Med1 subunit of transcriptional mediator plays a central role in regulating C/EBP--driven transcription in response to Interferon-g.Journal of Biological Chemistry  2008 May 9; 283(19):13077-86. 

8.PadmajaGade, Sanjit Roy, Hui Li, ShreeramNallar, and Dhan V. Kalvakolanu. A critical role for transcription factor C/EBP-betain regulating the expression of Death-associated protein kinase-1. Molecular & Cellular Biology  2008;28(8): 2528-48 

9.Hui Li, PadmajaGade, Weihua Xiao and Dhan V. Kalvakolanu.  The Interferon Signaling Network and Transcription Factor C/EBP-b.  Cellular & Molecular Immunology  2007;4(6):407-418. 

10.Hui Li,Jing Zhang, Ashok Kumar, Sally S.Atherton and Fu-shin X. Yu. HSV-1 infection induces the expression of proinflammatory cytokines, IFNs and TLR7 in human corneal epithelial cells. Immunology 2006, 117(2): 167-176.

11.Hui Li* & Xinxing Wu. Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. Bio Biophy Res Comm  2004, 324:860-867.

12.Hui Li & Janos Minarovits. Host cell-dependent expression of latent Epstein-Barr virus genomes: regulation by DNA methylation. Advances in Cancer Research 2003, 89:133-156.