医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是武汉大学六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759376
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵郭德银章晓联万芪李红良
千人计划入选: 霍文哲张发明、于学杰
青年千人计划入选: 陈实蒋卫钟波张好建、陈强、罗孟成、邓迎峰
百千万人才工程选者: 舒红兵、黄从新章晓联 
长江学者: 董晨舒红兵李红良
万人计划: 领军人才:舒红兵唐其柱李红良   青年拔尖人才: 刘天罡 、王连荣王培刚                
教育部新世纪优秀人才: 何小华 于红刚 李雁郑芳、胡锦跃、黄鹤
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姓名:何立

单位:武汉大学医学部基础医学院病原生物学系寄生虫学专业

职称:教授、博导

邮箱:heliandyuming@whu.edu.cn

联系电话:027-68759143

研究方向:

寄生虫感染免疫:重点研究血吸虫的免疫逃避机制,血吸虫感染的保护性免疫机制,以及血吸虫病的免疫防治。从日本血吸虫体内发现并证实了一个虫源性免疫抑制因子,并在动物实验中观察到具新型免疫调节剂类药物的潜在价值,并由此开辟了寄生虫功能基因在医学中的应用的研究领域。 

 











代表性论著:

代表性论著:

1. Chen Lin, Chen Qingzhou, Hou Wei, He Li*. High-throughput dynamic analysis of differentially expressed genes in splenic dendritic cells from mice infected with Schistosoma japonicum. Immunology Letters. 2017,184: 15-22.

2. Chen Lin, He Baohua, Hou Wei, He Li*. Cysteine protease inhibitor of Schistosoma japonicum ---A parasite derived negative immunoregulatory factor. Parasitology Research. 2017, 116(3): 901-908. 

3. Chen Lin, Chen Qing-zhou, Hou Wei, He Li*. The dynamic changes of CD3e(-)CD11c(+) dendritic cells in spleens and bone marrow of mice infected with Schistosoma japonicum. Parasitology Research. 2017, 116(3): 1008 -1011.

4. Xiong Yuan-Huan, Yuan Zhen, He Li*. Effects of estrogen on CD4(+) CD25(+) regulatory T cell in peripheral blood during pregnancy. Asian Pacific Journal of Tropical Medicine. 2013, 6(9): 748-752.

5. He Yuan, Cai Guobin, Ni Yonghui, Li Ying, Zong  Hongying), He Li*. siRNA-mediated knockdown of two tyrosinase genes from Schistosoma japonicum cultured in vitro. Experimental Parasitology. 2012, 132(4): 394-402.

6. He Baohua, Cai Guobin, Ni Yonghui, Li Ying, Zong  Hongying, He Li* Characterization and expression of a novel cystatin gene from Schistosoma japonicum. Molecular and Cellular Probes. 2011, 25(4): 186-193.

7. Cai Guobin, Bae Youngan, Zhang Ying, He Yuan, Jiang  Mingsen, He Li*. Expression and characterization of two tyrosinases from the trematode Schistosoma japonicum. Parasitology Research. 2009, 104(3): 601-609.

8. He Li, Gang Z, Yuling H, Luokun X, Jie X, Hao L, Li W, Chunsong H, Junyan L, Mingshen J, Youxin J, Feili G, Boquan J, Jinquan T. Different neurotropic pathogens elicit neurotoxic CCR9- or neurosupportive CXCR3-expressing microglia. J Immunol. 2006, 177(6): 3644-3656.

9. He Li, Yi XY, Jiang MS, Zeng XF, Ouyang L, McReynolds L. Schistosoma japonicum: establishment of a mouse model that demonstrates concomitant immunity. Chin Med J (Engl). 2004, 117(6): 947-949. 

10. He Li, Chunsong H, Guobin C, Qiuping Z, Qun L, Xiaolian Z, Baojun H, Linjie Z,Junyan L, Mingshen J, Jinquan T. Highly up-regulated CXCR3 expression on eosinophils in mice infected with Schistosoma japonicum. Immunology. 2004, 111(1): 107-117.